| 課程名稱 |
(中文) 分子生物學 (英文) Molecular Biology |
開課單位 | 化學工程與生物科技學系 | ||
| 課程代碼 | S4300 | ||||
| 授課教師 | 陳建先 | ||||
| 學分數 | 3.0 | 必/選修 | 選修 | 開課年級 | 大三 |
| 先修科目或先備能力：生物化學 | |||||
| 課程概述與目標：課程內容包含DNA結構、DNA複製、基因轉錄及基因轉譯的機制及調控.以及分子生物操作技術，期使學生了解分子遺傳之原理 | |||||
| 教科書 | David P. Clark & Nanette J. Pazdernik Molecular biology, 2ed. 滄海代理 |
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| 參考教材 | |||||
| 課程大綱 | 學生學習目標 | 單元學習活動 | 學習成效評量 | 備註 | ||
| 週 | 單元主題 | 內容綱要 | ||||
| 1 | Introduction | 1. 課程說明 2. Mendelian View of Genes |
瞭解學習目標及應配合事項 從遺傳到基因 |
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| 2 | History | 1. DNA Carry Genetic Specificity 2. Nucleic Acids convey genetic information 3. Estabilishing the Directionof Protein Synthesis |
遺傳歷史到近代基因技術 |
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| 3 | Structure and Study of Marcromolecules | 1. Weak and Strong Chemical Bonds 2. The Structure of DNA 3. The Structure of RNA |
生物分子間之鍵結及自由能在化學反應之應用, DNA及RNA之結構 |
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| 4 | Structure and Study of Macromolecules | 1. The Structure of Proteins 2. Thecniques of Molecular Biology |
介紹蛋白質r及分子生物研究相關實驗方法 |
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| 5 | Maintance of the Genome | Genome Structure, Chromatin, and teh Nucleosome | 染色體, 染色質體之結構及功能 |
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| 6 | The Replication of DNA | 1. The Chemistry of DNA Synthesis 2. The Mechanism of DNA Polymerase 3. The Replication Fork 4. The Specilization of DNA Polymerases |
DNA複製作用, DNA Pol, 複製機制之瞭解 |
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| 7 | The Replication of DNA | 5. DNA Synthesis at the REplication Fork 6. Iniciation of DNA Replication 7. Binding and Unwinding Related Proteins 8. Finishing Replication |
DNA 複製機制之解析, 三階段之說明 |
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| 8 | DNA Repair and Recombination | 1. DNA Damage and Reair 2. Homologous Recombination |
DNA 突變, 修補, 及重組 |
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| 9 | 期中考 | 從第一章到第十二章 | 測試學生對授課內容之理解 |
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| 10 | Mechanism of Transcription | RNA Polymerase and The Transcription Cycle | RNA Polymerase and The Transcription Cycle |
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| 11 | Expression of The Genome | 1. RNA splicing | RNA splicing |
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| 12 | Expression of The Genome | 1. Translation | Translation |
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| 13 | Expression of The Genome | Translation | Translation |
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| 14 | Expression of The Genome | The Genetic Code | Genetic Code |
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| 15 | Regulation | Transcriptional Regulation in Prokaryotes | Transcriptional Regulation in Prokaryotes |
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| 16 | Regulation | Translational Regulation in Eukaryotes | Translational Regulation in Eukaryotes |
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| 17 | 期末考 | 以轉錄機制, RNA splicing, 轉譯, 基因秘碼, 及轉錄調控為主 | 測試學生對基因表現及調控之理解程度 |
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| 18 | 期末考週 | 公布答案、成績及檢討考卷 | 糾正錯誤觀念，提升學習成效 |
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教學要點概述： |