教學大綱表 (114學年度 第1學期)
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課程名稱
Course Title		 (中文) 生化工程學(二)
(英文) Biochemical Engineering 		開課單位
Departments		 化學工程與生物科技學系
課程代碼
Course No.		 S4312
授課教師
Instructor		 游吉陽
學分數
Credit		 3.0 必/選修
core required/optional		 選修 開課年級
Level		 大四
先修科目或先備能力(Course Pre-requisites)：
課程概述與目標(Course Overview and Goals)： 對生物原料之處理及利用生物分子進行之程序一直是化學工業重要之一環。本課程結合生化、微生物、工程數學及化學工程之基礎，對前述之程序以工程及量化之角度進行探討
教科書(Textbook) Bioprocess Engineering, ML Shuler and F Kargi, 2nd edition, Prentice Hall, 2002
參考教材(Reference) Biochemical Engineering Fundamentals, JE Bailey and DF Ollis, 新月
Biochemical Engineering, JM Lee, Prentice Hall
課程大綱 Syllabus 學生學習目標
Learning Objectives		 單元學習活動
Learning Activities		 學習成效評量
Evaluation		 備註
Notes
序
No.		 單元主題
Unit topic		 內容綱要
Content summary
1 What is a bioprocess engineer? 1. Introductory remarks
2. Biotechnology and bioprocess engineering
3. Biologists and Engineers differ in their approach to research
4. The story of penicillin
5. Bioprocesses: regulatory constraints 		了解What is a bioprocess engineer 講授
 		 
2 Enzymes 1. Introduction
2. How enzymes work 		了解How enzymes work 講授
 		 
3 Enzymes 1. Enzyme kinetics
2. Immobilized enzyme systems 		了解Enzyme kinetics、Immobilized enzyme systems 講授
 		 
4 Enzymes 1. Large-scale production of enzymes
2. Medical and industrial utilization of enzymes
3. Summary 		了解Large-scale production of enzymes、Medical and industrial utilization of enzymes 講授
 		 
5 How cells grow 1. Introduction
2. Batch growth
3. Quantifying growth kinetics 		了解 Batch growth、Quantifying growth kinetics 講授
 		 
6 How cells grow 1. How cells grow in continuous culture
2. Summary 		了解How cells grow in continuous culture 講授
 		 
7 Stoichiometry of microbial growth and product formation 1. Introduction
2. Some other definitions
3. Stoichiometry calculations 		了解Stoichiometry calculations 講授
 		 
8 midterm exam midterm exam midterm exam 期中考
 		 
9 Stoichiometry of microbial growth and product formation 1. Theoretical predictions of yield coefficients
2. Summary 		了解Theoretical predictions of yield coefficients 講授
 		 
10 Operating considerations for bioreactors for suspension and immobilized cultures 1. Introduction
2. Choosing the cultivation method 		了解Choosing the cultivation method 講授
 		 
11 Operating considerations for bioreactors for suspension and immobilized cultures 1. Modifying batch and continuous reactors
2. Immobilized cell systems 		了解Modifying batch and continuous reactors、Immobilized cell systems 講授
 		 
12 Operating considerations for bioreactors for suspension and immobilized cultures 1. Solid-state fermentation
2. Summary 		了解Solid-state fermentation 講授
 		 
13 Selection, scale-up, operation, and control of bioreactors 1. Introduction
2. Scale-up and its difficulties 		了解Scale-up and its difficulties  
14 Selection, scale-up, operation, and control of bioreactors Bioreactor instrumentation and control 了解Bioreactor instrumentation and control  
15 Selection, scale-up, operation, and control of bioreactors 1. Sterilization of process fluids
2. Summary 		了解Sterilization of process fluids  
16 final exam final exam final exam 期末考
 		 
彈性教學週活動規劃
序
No.		 實施期間
Period		 實施方式
Content		 教學說明
Teaching instructions		 彈性教學評量方式
Evaluation		 備註
Notes
1 起:2025-12-29 迄:2026-01-11 5.小專題 Project term project based on enzyme databases 成果報告 無


教學要點概述：
1.自編教材 Handout by Instructor：
■ 1-1.簡報 Slids
■ 1-2.影音教材 Videos
□ 1-3.教具 Teaching Aids
■ 1-4.教科書 Textbook
□ 1-5.其他 Other
□ 2.自編評量工具/量表 Educational Assessment
□ 3.教科書作者提供 Textbook

成績考核 Performance Evaluation： 期末考：20%   期中考：20%   其他評量：10%   彈性教學：10%   平時考：40%  

教學資源(Teaching Resources)：
■ 教材電子檔(Soft Copy of the Handout or the Textbook)
□ 課程網站(Website)
扣考規定：https://curri.ttu.edu.tw/p/412-1033-1254.php