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課程名稱 (中文) 生化工程學(二)
(英文) Biochemical Engineering 		開課單位 生物工程學系
課程代碼 S4312
授課教師 陳志成 游吉陽
學分數 3.0 必/選修 選修 開課年級 大三
先修科目或先備能力：需修習生化工程一
課程概述與目標： 對生物原料之處理及利用生物分子進行之程序一直是化學工業重要之一環。本課程結合生化、微生物、工程數學及化學工程之基礎，對前述之程序以工程及量化之角度進行探討
教科書 Bioprocess Engineering, ML Shuler and F Kargi, 2nd edition, Prentice Hall, 2002
參考教材 Biochemical Engineering Fundamentals, JE Bailey and DF Ollis, 新月
Biochemical Engineering, JM Lee, Prentice Hall
課程大綱 學生學習目標 單元學習活動 學習成效評量 備註
週 單元主題 內容綱要
1 What is a bioprocess engineer? 1. Introductory remarks
2. Biotechnology and bioprocess engineering
3. Biologists and Engineers differ in their approach to research
4. The story of penicillin
5. Bioprocesses: regulatory constraints 		了解What is a bioprocess engineer
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    2 Enzymes 1. Introduction
    2. How enzymes work     		了解How enzymes work
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    3 Enzymes 1. Enzyme kinetics
    2. Immobilized enzyme systems     		了解Enzyme kinetics、Immobilized enzyme systems
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    4 Enzymes 1. Large-scale production of enzymes
    2. Medical and industrial utilization of enzymes
    3. Summary     		了解Large-scale production of enzymes、Medical and industrial utilization of enzymes
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    5 How cells grow 1. Introduction
    2. Batch growth
    3. Quantifying growth kinetics     		了解 Batch growth、Quantifying growth kinetics
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    6 How cells grow 1. How cells grow in continuous culture
    2. Summary     		了解How cells grow in continuous culture
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    7 Stoichiometry of microbial growth and product formation 1. Introduction
    2. Some other definitions
    3. Stoichiometry calculations     		了解Stoichiometry calculations
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    8 Stoichiometry of microbial growth and product formation 1. Theoretical predictions of yield coefficients
    2. Summary     		了解Theoretical predictions of yield coefficients
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    9 期中考 期中考 期中考
  • 期中考
  • 出席成績
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    10 Operating considerations for bioreactors for suspension and immobilized cultures 1. Introduction
    2. Choosing the cultivation method     		了解Choosing the cultivation method
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    11 Operating considerations for bioreactors for suspension and immobilized cultures 1. Modifying batch and continuous reactors
    2. Immobilized cell systems     		了解Modifying batch and continuous reactors、Immobilized cell systems
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    12 Operating considerations for bioreactors for suspension and immobilized cultures 1. Solid-state fermentation
    2. Summary     		了解Solid-state fermentation
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    13 Selection, scale-up, operation, and control of bioreactors 1. Introduction
    2. Scale-up and its difficulties     		了解Scale-up and its difficulties
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    14 Selection, scale-up, operation, and control of bioreactors Bioreactor instrumentation and control 了解Bioreactor instrumentation and control
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    15 Selection, scale-up, operation, and control of bioreactors 1. Sterilization of process fluids
    2. Summary     		了解Sterilization of process fluids
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    16 Recovery and purification of products 1. Strategies to recover and purify products
    2. Separation of insoluble products
    3. Cell disruption     		了解Strategies to recover and purify products、Separation of insoluble products、Cell disruption
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    17 Recovery and purification of products 1. Separation of soluble products
    2. Finishing steps for purification     		了解Separation of soluble products、Finishing steps for purification
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    18 期末考 期末考 期末考
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