X5580 教學大綱表

教學大綱表 (114學年度第1學期)

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課程名稱 Course Title	(中文) 生物學與材料學之間的交互作用 (英文) The Intersection Of Biology And Materials Science			開課單位 Departments	材料工程研究所
				課程代碼 Course No.	X5580
授課教師 Instructor	吳錫芩
學分數 Credit	3.0	必/選修 core required/optional	選修	開課年級 Level	研究所
先修科目或先備能力(Course Pre-requisites)：Suitable for third-year and above undergraduate students (including graduate students) in the College of Engineering, this course is an introductory application course in the interdisciplinary field of biomedical sciences. 適合工學院大學部三年級以上（含研究所）學生，本課程屬跨域生物醫學領域初階應用課程。
課程概述與目標(Course Overview and Goals)：This course presents the basic fundamentals of materials science on a level appropriate for students. Each topic, including metals, ceramics, polymers, composite, and further advanced materials, ranges from fundamental theories and principles to in-depth medical applications. The objective is to discuss and understand how material engineering approaches can be designed, the discipline of materials science and engineering, and their interrelationship in medicine. 1. Materials for Biomedical Applications 2. Chemical Structure of Biomaterials 3. Physical Properties of Biomaterials 4. Mechanical Properties of Biomaterials 5. Biomaterial Degradation 6. Biomaterial Processing 7. Surface Properties of Biomaterials 8. Protein Interactions with Biomaterials 9. Cell Interactions with Biomaterials 10. Biomaterial Implantation and Acute Inflammation 11. Wound Healing and the Presence of Biomaterials 12. Immune Response to Biomaterials 13. Biomaterials and Thrombosis 14. Infection, Tumorigenesis, and Calcification of Biomaterials 本課程介紹材料科學的基本原理，以金屬、陶瓷、聚合物、複合材料和先進材料等在內的主題，由基礎理論和原理切入，延伸至醫學領域應用進行探討。課程主要目的是讓非生物醫學領域背景的學生，建立以工程跨域的角度來考量與設計應用於生物醫學領域的思維，並理解及衡量之間的相互關係。
教科書(Textbook)	Fundamentals of biomaterials, V Hasirci, N Hasirci - 2018 - Springer Biomaterials: the intersection of biology and materials science Pearson Prentice Hall bioengineering, J. S. Temenoff, Antonios G. Mikos, Pearson Prentice Hall, 2008 (ISBN 0132350440, 9780132350440)
參考教材(Reference)	Biomaterials: An Introduction, Joon Park,R.S. Lakes, Springer-Verlag
圖書館電子書(E-book of the Library)	Fundamentals of biomaterials [electronic resource] Second edition. Hasirci, Vasif. https://link.springer.com/book/10.1007/978-3-031-54046-2

課程大綱 Syllabus			學生學習目標 Learning Objectives	單元學習活動 Learning Activities	學習成效評量 Evaluation	備註 Notes
序 No.	單元主題 Unit topic	內容綱要 Content summary	學生學習目標 Learning Objectives	單元學習活動 Learning Activities	學習成效評量 Evaluation	備註 Notes
1	課程介紹 The history and scope of biomaterials	課程規劃與實施方式 The history and scope of biomaterials The course planning and implementation method	了解課程學習內容摘要 Understand the summary of course learning content	討論講授	其他評量-	課堂觀察Observation、課堂參與Class participation、問卷Questionnaire
2	簡介：生醫材料 Introduction: Biomaterials	重要定義 Important Definitions 生醫材料的歷史與現狀 History and Current Status of the Field 生醫材料的生物反應性 Biological Response to Biomaterials 生醫材料產品測試與FDA認證 Biomaterial Product Testing and FDA Approval	學生將能夠掌握生醫材料的重要定義、歷史背景及其在現代醫學中的應用範疇。Understand key concepts of biomaterials, their historical context, and applications in modern medicine. 學生將學習如何評估生物組織對生醫材料的相容性與潛在影響。Analyze biological responses to biomaterials, including tissue compatibility and potential impacts. Gain familiarity with product testing processes and FDA regulatory requirements for biomaterials.	討論演講	平時考其他評量-	*生醫材料產品測試與FDA認證 Biomaterial Product Testing and FDA Approval 課堂觀察Observation、課堂參與Class participation、問答評估 Q&A assessment、討論紀錄Discussion record
3	材料在生物醫學領域的應用(I)（金屬、陶瓷、高分子、複合材） Applications of Materials in the Biomedical Field (I) (Metals, Ceramics, Polymers, Composites	生醫材料的類型：金屬材料、陶瓷材料、高分子材料（天然聚合物與合成聚合物）、 Types of Biomaterials：Metals, Ceramics, Polymers（Naturally Derived vs. Synthetic Polymers）, 生醫材料的加工處理 Processing of Biomaterials 生醫材料的重要特性：降解特性、表面特性、整體特性、分析技術 Important Properties of Biomaterials：Degradative Properties, Surface Properties, Bulk Properties, Characterization Techniques	學生將能夠區分金屬、陶瓷及聚合物等不同類型生醫材料，並掌握其應用範疇與特性。 Identify and differentiate the various types of biomaterials such as metals, ceramics, and polymers, and their respective applications and properties.	討論講授媒體教學個案研究閱讀討論	平時考其他評量-	課堂觀察Observation、課堂參與Class participation、問答評估 Q&A assessment、討論紀錄Discussion record
4	材料在生物醫學領域的應用(II)（金屬、陶瓷、高分子、複合材） Applications of Materials in the Biomedical Field (II) (Metals, Ceramics, Polymers, Composites	生醫材料的類型：金屬材料、陶瓷材料、高分子材料（天然聚合物與合成聚合物）、 Types of Biomaterials：Metals, Ceramics, Polymers（Naturally Derived vs. Synthetic Polymers）, 生醫材料的加工處理 Processing of Biomaterials 生醫材料的重要特性：降解特性、表面特性、整體特性、分析技術 Important Properties of Biomaterials：Degradative Properties, Surface Properties, Bulk Properties, Characterization Techniques	理解並能選用材料（金屬、陶瓷、高分子、複合材）設計應用於生物醫學領域 Understand and be able to select materials (metals, ceramics, polymers, composites) for design applications in the biomedical field 學生將學習生醫材料的常見加工方法及其對材料性能的影響。 Understand the processing methods of biomaterials and their impact on material properties.	討論講授媒體教學個案研究閱讀討論	平時考其他評量-	課堂觀察Observation、課堂參與Class participation、問答評估 Q&A assessment、討論紀錄Discussion record
5	材料在生物醫學領域的應用(III)（金屬、陶瓷、高分子、複合材） Applications of Materials in the Biomedical Field (III) (Metals, Ceramics, Polymers, Composites	生醫材料的類型：金屬材料、陶瓷材料、高分子材料（天然聚合物與合成聚合物）、 Types of Biomaterials：Metals, Ceramics, Polymers（Naturally Derived vs. Synthetic Polymers）, 生醫材料的加工處理 Processing of Biomaterials 生醫材料的重要特性：降解特性、表面特性、整體特性、分析技術 Important Properties of Biomaterials：Degradative Properties, Surface Properties, Bulk Properties, Characterization Techniques	學生將探討生醫材料的降解特性、表面特性、體積特性，並學習如何使用特定技術進行分析。 Analyze key properties of biomaterials, including degradative, surface, and bulk characteristics, and utilize characterization techniques effectively.	討論講授媒體教學個案研究閱讀討論	平時考其他評量-	課堂觀察Observation、課堂參與Class participation、問答評估 Q&A assessment、討論紀錄Discussion record
6	學生發表：材料分析技術(I) Student Oral Presentation and discussion: Material Analysis Techniques(I)	掃描式電子顯微鏡 Scanning electron microscopy (SEM) 穿透式電子顯微鏡 Transmission Electron Microscopy (TEM) 能量散射X射線譜 Energy-dispersive X-ray spectroscopy (EDS) 萬能試驗機 Universal Testing Machine：拉伸tensile及壓縮 compression 熱重分析儀 Thermogravimetry Analyzer (TGA) 熱差分析儀 Differential Thermal Analyzer (DTA)/ Differential Scanning Calorimetry (DSC) X射線繞射儀 X-ray diffractometer (XRD)	學生將了解和掌握如顯微鏡技術、熱分析、光譜、結構分析等多種特定技術的基本原理與應用場景。 Understand and become proficient in various characterization techniques such as microscopy, thermal analysis, spectroscopy, and structural analysis.	討論講授心得發表個案研究閱讀討論	作業報告其他評量-	作業 Assignment、報告 Presentation、同儕互評Peer assessment、課堂觀察Observation、課堂參與Class participation、問卷Questionnaire
7	學生發表：材料分析技術(II) Student Oral Presentation and discussion: Material Analysis Techniques(II)	核磁共振光譜法 Nuclear Magnetic Resonance spectroscopy (NMR) 高效液相層析儀 high performance liquid chromatography (HPLC) 質譜儀 mass spectrometer (MS) 傅里葉轉換紅外光譜 Fourier-transform infrared spectroscopy (FTIR) 紫外-可見分光光度法 Ultraviolet–visible spectroscopy (UV-Vis) 界面電位分析儀Zeta Potential Measurement 動態光散射粒徑分析Dynamic light scattering (DLS) 流變儀 Rheometer (DHR)	學生將能應用分析技術，並進一步解釋實驗結果於材料的物理與化學特性研究中。 Apply analytical techniques to interpret experimental data in the study of the physicochemical properties of materials. 應用及評估材料分析技術用於生物醫學領域 Application and evaluation of materials analysis techniques in biomedical applications	討論講授心得發表個案研究閱讀討論	作業報告其他評量-	作業 Assignment、報告 Presentation、同儕互評Peer assessment、課堂觀察Observation、課堂參與Class participation、問卷Questionnaire
8	期中測驗：材料分析技術檢核 Mid-term：Evaluation of Biomaterial Analysis Techniques 期中專題討論 Midterm Project Discussion	期中測驗：材料分析技術檢核 Mid-term：Evaluation of Biomaterial Analysis Techniques 期末專案主題：[發想、探討] Final Project Topics：Step (I) [Ideation, Exploration]	檢視學生對於各種材料分析技術的基本原理與應用的理解。 Assess students' understanding of the principles and applications of various biomaterial analysis techniques 培養設計和開發創新醫療應用生物材料的能力 Develop the ability to design and development of biomaterials for innovative medical applications. *另請見「備註說明Notes」		平時考其他評量-	*針對期中專案的主題，進行小組討論與初步設計，學習團隊合作並發展解決問題的能力。 Engage in group discussions and preliminary designs for the midterm project, fostering teamwork and problem-solving skills. 測驗Exam、專案提案討論學習單 Project propose worksheet、課堂觀察Observation、課堂參與Class participation
9	文獻導讀、案例討論 Literature Review, Case Study 專案設計發想與探討（定義問題、使用者需求-歸納已知&未知訊息、擬定需求、挑戰重點） Project Design and Exploration (Defining Problems, User's Needs - Inducing Known & Unknown Information, Formulating Requirements, Identifying Key Challenges)	生醫材料研發真實性問題情景設定（探索需求、詮釋需求） Realistic Scenario in Biomedical Research and Development (Exploring Needs, Interpreting Demands) （課程發想、原型實驗） Ideation, prototyping experiments	建立各種生醫材料結構、特性、應用之間的關聯性 Establishing the Correlation between Various Biomaterial Structures, Properties, and Applications 分析和解釋選定的學術文章，確定關鍵論點、方法論和結論。 Analyze and interpret selected academic articles, identifying key arguments, methodologies, and conclusions. *另請見「備註說明Notes」	討論講授個案研究閱讀討論	作業其他評量-	透過比較和對照文章中提出的不同觀點，增強批判性思考能力。 Enhance critical thinking skills by comparing and contrasting different perspectives presented in the articles. 總結每篇文章的要點並討論它們與課程主題的相關性。 Summarize the main points of each article and discuss their relevance to the course topics. 作業 Assignment、課堂觀察Observation、課堂參與Class participation
10	文獻導讀、案例討論 Literature Review, Case Study 進行主題構思的綜合討論 General Discussion on Theme Ideation	期末專案主題：[收斂、深入] Final Project Topics：Step (II) [Convergence, In-Depth] 探討與生醫材料相關的最新研究文獻與實際案例，培養批判性思考能力。 Exploration of recent research and case studies related to biomaterials, fostering critical thinking skills. 進行主題討論，發展創新且具實際應用性的專案方向。 Discussion and brainstorming to develop innovative and practical project ideas.	能夠閱讀、分析與批判生醫材料相關文獻及案例。 Ability to read, analyze, and critique biomaterial-related literature and cases. 能分析和解釋選定的學術文章，並指出關鍵論點、方法論和結論。 Analyze and interpret selected academic articles, identifying key arguments, methodologies, and conclusions. *另請見「備註說明Notes」	討論講授個案研究閱讀討論	作業其他評量-	透過比對文章中提出的不同觀點，增強批判性思考能力。 Enhance critical thinking skills by comparing and contrasting different perspectives presented in the articles. 總結每篇文章的精要之處並討論它們與課程主題的相關性。 Summarize the main points of each article and discuss their relevance to the course topics. 作業 Assignment、課堂觀察Observation、課堂參與Class participation
11	個案研究、心得發表、閱讀討論(I) Student's project design/ proposal presentation、Selected articles reading(I)	分析實際案例與選讀相關文獻，結合理論與實務以提升學習效果。 Case study analysis and reading selected articles to integrate theory and practice for enhanced learning. 學生提出專案設計或研究構想，進行小組或全班討論與回饋。 Students present project designs or research proposals, followed by group or class discussions and feedback.	能深入分析個案與文獻內容，從中學習解決實際問題的方法。 Develop the ability to analyze and interpret case studies and literature for practical problem-solving. 能清晰地闡述專案設計或研究構想，並有效應對討論中的建議與問題。 Enhance skills in presenting project designs or research ideas and responding effectively to feedback during discussions.	討論心得發表個別或小組指導個案研究閱讀討論	作業報告其他評量-	報告 Presentation、同儕互評Peer assessment、作業 Assignment、課堂觀察Observation、課堂參與Class participation、專案提案討論學習單 Project propose worksheet
12	個案研究、心得發表、閱讀討論(II) Student's project design/ proposal presentation、Selected articles reading(II)	學生針對學習內容進行反思與總結，提出個人見解並與同儕分享。 Students reflect on and summarize learning outcomes, presenting personal insights and sharing with peers.	通過心得發表，提升批判性思考能力，並能結合學習內容形成新的觀點。 Promote reflective and critical thinking skills by expressing insights and forming new perspectives based on learning. 在討論與分享過程中，增進協作能力，學會傾聽與表達。 Strengthen teamwork and communication skills through active participation in discussions and sharing sessions.	討論心得發表個別或小組指導個案研究閱讀討論	作業報告其他評量-	報告 Presentation、同儕互評Peer assessment、作業 Assignment、課堂觀察Observation、課堂參與Class participation、專案提案討論學習單 Project propose worksheet
13	文獻導讀、案例討論 Literature Review, Case Study 生醫材料產業研發實例（一） Case Study: Industrial Research and Development (I)	生醫材料研發真實性問題情景設定（探索需求、詮釋需求） Realistic Scenario in Biomedical Research and Development (Exploring Needs, Interpreting Demands) （課程發想、原型實驗） Ideation, prototyping experiments	具備發展創新性專案構思的能力，並能進行理論與應用結合的探討。 Capability to develop innovative project ideas and integrate theory with application. 能針對特定生醫材料議題，進行深入的實驗設計、問題分析與解決。 Ability to conduct in-depth experimental designs, analyze issues, and propose solutions for biomaterials-related topics. *另請見「備註說明Notes」	討論心得發表協同教學個別或小組指導個案研究閱讀討論	作業報告其他評量-	*能夠有效地參與團隊合作與專案討論，並清晰地表達研究成果。 Ability to collaborate effectively in teams, engage in discussions, and present research outcomes clearly. 課堂觀察Observation、課堂參與Class participation、專案提案討論學習單 Project propose worksheet、討論紀錄Discussion record
14	生醫材料產業研發實例(II) Case Study: Industrial Research and Development (II) 專題設計草案調整、探討與討論 Project design draft adjustments, exploration, and discussion	專案設計發想與探討（定義問題、使用者需求-歸納已知&未知訊息、擬定需求、挑戰重點） Project Design and Exploration (Defining Problems, User's Needs - Inducing Known & Unknown Information, Formulating Requirements, Identifying Key Challenges)	新創醫材問題對策、發展、實行 Problem Solving, Development, and Implementation of Innovative Medical Devices 檢視團隊本身的創意、創作與競爭者的差別，創意發想。 Assessing the team's creativity, originality, and differentiation from competitors, as well as brainstorming creative ideas	討論設計研究協同教學個別或小組指導個案研究閱讀討論	作業報告其他評量-課堂表現	課堂觀察Observation、課堂參與Class participation、專案提案討論學習單 Project propose worksheet、討論紀錄Discussion record
15	檢核原型模擬/實作（II）：雛形 Evaluating Prototype Simulation/ Implementation review(II): prototype 期末專案主題：[主題發想、預報+討論] Final Project Topics：Step (III) [Forecast, and Discussion]	專題設計草案調整、探討與討論 Project design draft adjustments, exploration, and discussion	透過展演報告有效地傳達專案目標、方法和預期成果。 Effectively communicate project objectives, methodology, and expected outcomes through a professional presentation. 針對同儕的展演報告能提出批判性地看法，並提供有關專案設計和展演技巧的建設性回饋。 Critically evaluate peer presentations, providing constructive feedback on project design and presentation skills.	討論設計研究個別或小組指導閱讀討論	作業報告其他評量-課堂表現	報告 Presentation、同儕互評Peer assessment、作業 Assignment、課堂觀察Observation、課堂參與Class participation、問卷Questionnaire
16	學生根據學期學習內容，設計專題研究，涵蓋問題定義、材料選擇、技術應用與創新思維。 Students design a research project based on semester learning, including problem definition, material selection, technical application, and innovative thinking. 期末專題報告 Project Design Presentation	撰寫完整的專題報告，並進行小組或個人展示，呈現研究成果與分析。 Prepare a comprehensive project report and deliver group or individual presentations showcasing research findings and analysis. 教師與同學提供回饋，進一步完善專題研究的設計與內容。 Receive feedback from instructors and peers to refine project designs and content.	將課堂所學整合於專題研究中，深入探索材料科學於生醫應用的實踐可能性。 Integrate classroom knowledge into project research, exploring the practical applications of materials science in biomedicine. 培養學生分析問題與設計解決方案的能力，發展創新的研究思維。 Develop students’ abilities to analyze problems and design solutions, fostering innovative research thinking.	討論設計研究心得發表協同教學個別或小組指導個案研究	作業報告其他評量-	*提升學生在專業報告中清晰表達想法與成果的能力。 Enhance students' skills in effectively presenting ideas and findings in professional reports. 學會接受專業回饋，並進一步改進研究方法與成果。 Learn to accept constructive feedback and improve research methods and outcomes. 報告 Presentation、同儕互評Peer assessment、作業 Assignment、課堂觀察Observation、課堂參與Class participation、問卷Questionnaire
17	[彈性補充教學週次]Flexible Supplemental Instruction Week 校外參訪教學活動 Off-Campus Field Trip Teaching Activity (Teacher-Guided Visit)	台灣醫療科技展2025 Taiwan Healthcare Expo（每年12月第一週） https://expo.taiwan-healthcare.org/zh/index.php 展覽時間：2025.12.04(四)-12.06(六) 10:00 - 18:00 2025.12.07(日) 10:00 - 16:00 展覽地點：南港展覽館一館 (115 台北市南港區經貿二路1號)	探索最新的醫療科技發展與創新成果 Expo to explore the latest advancements and innovations in healthcare technology. 瞭解並分析生醫產業發展及態勢 Understand and analyze the development and trends of the biomedical industry 深入了解醫療技術的應用與前景 gain insights into medical technology applications and prospects *另請見「備註說明Notes」	參訪探索體驗	作業其他評量-課堂表現彈性教學	*將課堂所學與醫療科技展的觀察結合，深化對材料與工程在醫療中的應用理解。 Enhance interdisciplinary integration by linking classroom knowledge with observations from the expo to deepen understanding of material and engineering applications in healthcare. 活動回饋心得Activity experience, opinion and feedback、活動參與 Acivity Participation
18	[彈性補充教學週次]Flexible Supplemental Instruction Week 期末評估、反思、回顧/回饋 Evaluation, Reflection, Review/Feedback	期末評估、反思、回顧/回饋 Evaluation, Reflection, Review/Feedback	期末評估、反思、回顧/回饋 Evaluation, Reflection, Review/Feedback	討論心得發表	作業報告其他評量-課堂表現彈性教學	期末評估、反思、回顧/回饋 Evaluation, Reflection, Review/Feedback

彈性教學週活動規劃

序 No.	實施期間 Period	實施方式 Content	教學說明 Teaching instructions	彈性教學評量方式 Evaluation	備註 Notes
1	起:2024-01-01 迄:2024-01-07	5.小專題 Project	Project Validation/Implementation Evaluation 檢核專案驗證/實作	Developing students’ oral and written communication skills, enhancing problem-solving abilities, and fostering critical thinking skills. 培養同學口語及書面溝通能力，增進解決問題能力及批判思考能力。
2	起:2024-01-08 迄:2024-01-14	2.非同步線上課程 Asynchronous online course	Evaluation, Reflection, Review/Feedback 期末評估、反思、回顧/回饋	Evaluation, Reflection, Review/Feedback 期末評估、反思、回顧/回饋

教學要點概述：
1.自編教材 Handout by Instructor：
■ 1-1.簡報 Slids
■ 1-2.影音教材 Videos
□ 1-3.教具 Teaching Aids
□ 1-4.教科書 Textbook
□ 1-5.其他 Other
■ 2.自編評量工具/量表 Educational Assessment
□ 3.教科書作者提供 Textbook

成績考核 Performance Evaluation：其他評量：30% 報告：20% 彈性教學：10% 平時考：20% 作業：20%

教學資源(Teaching Resources)：
□ 教材電子檔(Soft Copy of the Handout or the Textbook)
■ 課程網站(Website)
課程網站(Website)：Tronclass
扣考規定：https://curri.ttu.edu.tw/p/412-1033-1254.php